The following common genetic diseases can cause male infertility.

(1) Klinefelter's syndrome : It has many names, such as small quantities of achondroplasia. Qu seminiferous tubule degeneration atherosclerotic disease, congenital hypoplasia invest Lung Disease, a small primary testicular disease. The disease in adolescence ago, a slight, I often go unnoticed. Typical symptoms of testicular adolescence to small and hard, not more than two centimeters in diameter. about half the normal length of the average adult man. Is slender, delicate skin, long hair. Sparse beard, showed that about half of feminine breasts in adolescent sexual function without the ability to reproduce. Some patients have mild mental retardation. Qu testicular biopsy shows hyalinizing seminiferous tubules, thickening of the basement membrane significantly, the spermatogenic cells shrink or disappear. Only cells, multi-cavity occlusion. Leydig collagen fibers proliferated, stromal cell clusters, reduce cell lipid droplets. Normal or low levels of serum testosterone, estrogen production volume increased, the ratio between the two disorders. Most cases of blood, urine gonadotropin significantly increased, in particular the most significant FSH levels. Semen little or no sperm quantity of sperm.

(2) XX male syndrome (XXmales) : This syndrome chromosome type was 46, XX. However, external genitalia of male to male secondary sexual characteristics adolescent showing off. Clinical manifestations, pathology and similar endocrine inspection Klinefelter syndrome.

(3) No testes syndrome (Anorchia) : normal male karyotype of the disease-46, XY, external genitals were men, but congenital testicle, the result of adolescent sexual maturity is not showing the various performances. Most importantly for the naive, small penis, impotence and infertility has so. Blood-rate low gonadotropin levels, the typical single primary dysfunction pill.

(4) : Known as Rosewater's syndrome gonadal function feminization of familial breast disease. The patients appeared breast development in adolescence, and acinar breast ductal hyperplasia can be seen live thrifty, no category hypotestosterone physique. no male secondary sexual characteristics, sexual desire is low, the majority of them, have a small penis and prostate, testis size near normal. Qu Jian seminiferous tubules can be seen live testicular germ cells were stagnant, the number of interstitial cells. Army plasma ketone levels lower estrogen excretion in urine, to reduce emission of gonadotropin.

(5), also known as Kallmann's syndrome : a familial sexual olfactory nerve hypoplasia syndrome. Hypoplastic mainly as a single pill, especially during adolescence when there are no secondary sexual characteristics. Testicular small penis as a child like no single disease. Smell dissipated or congenital deficiency was found in some patients following the olfactory brain disease or defect leaves hypoplasia. Also have other congenital anomalies, such as cryptorchidism, cleft lip, cleft palate, color blindness, nerve deafness, congenital renal anomalies. Laboratory examination showed lower serum gonadotropin both LH and FSH, testosterone were significantly lower, Urine 17 Ketosteroid also declined. No sperm or semen without sperm. Testicular biopsy showed small quantities of immature, small-caliber, spermatogenic cells significantly reduced relative increase in the number of cells. no sperm. Leydig cells close or reduce the stromal cells, secretion of pituitary hormone were normal.

In addition, some other genetic diseases caused by infertility, should also be noted. Most of the history of these patients have a close relative married, or living in remote mountain villages and water districts, often family. need to seriously investigate, timely detection and treatment.

This article was posted on 2007-02-27