Penicillin prejudice to the role of the composition of bacterial cell wall synthesis (wall sticky peptide). Since bacteria can not create the bacterial cell wall and lost a solid wall of protection, deformation bacteria, swelling or dissolved; no cell wall synthesis, bacteria can not breed even survive, it is very difficult, so the high concentration of penicillin. Not only can inhibit the growth and reproduction of bacteria, but also sterilization. Since the bactericidal effect of penicillin main cocci, also on ECM to mention a strong kill. Penicillin can be quickly absorbed into the blood after intramuscular, intravenous plasma concentration reached its peak more quickly, They can be quickly infiltrated organizations and secretions, but in brain and nerve tissue, CSF and other places, less content, because it is not easily through the blood-brain barrier, which is why the bacteria invade the meninges, the effect of penicillin as sulfonamides. But the flow of meningitis bacteria can quickly reach high concentrations of penicillin soon bactericidal than SD superiority. Therefore, the shock of meningitis or septicemia period, the patients did not use SD urine when fears of kidney damage At this point chosen after treatment with penicillin. Dose per kilogram of body weight per day for 15 children if 200,000 units. Adult day event no less than eight million units in 1400, 4-6 pm intramuscular or intravenous drip. Since penicillin is not easy through the blood-brain barrier, a low level of brain tissue in order to achieve effective bactericidal concentration. In recent years, also proposed a large dose of short-term methods of treatment, 3.2 million units of penicillin for adults 80-l00 ml of 10% glucose solution. 1 hour after infusion, 2-3 days treatment. In this method, because of the shortened course, reduce the burden on the patient, long-term infusion, but also produce better results. It has been reported up to 98% efficiency for our reference application.

This article was posted on 2007-02-27